Pathologic _'s general knowledge of the viral myocarditis

Pathologic _'s general knowledge of the viral myocarditis
Though the world has not been totally distinct yet to the pathogenesis of viral myocarditis at present, train, beat myocardium cell infect strange the intersection of B and the intersection of group and virus Sa Ke, cause myocardium the intersection of pathological change and foundation of model with modern viral the intersection of myocarditis and the intersection of experimental animal and model, take place elucidation of mechanism for very much loud development to disease this. Thought course of this disease had two stages in the past: The virus duplicates one; Abnormal reaction period of the immunity. But the result of study has shown recently, the first stage is except that virus has duplicated and damaged the cardiac muscle directly, also there is cell immunity that damages the course.
The pathology of the viral myocarditis changes and can be divided into cooking stove and filling the air myocarditis of a office; The substance and a quality myocarditis. Substantive myocarditis is that the pathology of regarding myocardium cells are dissolved, necrosis, changing the sex and swelling as the main characteristic changes. Among inflammation at connective tissue by fibers myocardium and around blood vessel quality myocarditis the cells be changed to pathology of main fact to be soaked. Change example into with strange the intersection of virus and the intersection of myocarditis and pathology that B3 is infect with Sa Ke, until acute early periods have myocardium the intersection of cell and swelling, cell horizontal line unclear, afterbirth thick liquid dye, have a liking for acid to strengthen, nucleus appear firm to contract core and core crack. It is early not to see inflammation cells soak yet, myocardium cells disappear subsequently, soak for the inflammation cells of the main fact monocyte and lymphocyte around, the blue particulate matter of calcification increases, form scatteredly and soak in the point-like, cooking stove or slice myocardium cell necrosis and inflammation cell in the necrosis cooking stove, there are too many to give much trouble the quality and blood vessel among the heart. Some viral myocarditis enters chronic one. It is that a inflammation cell is reduced gradually that its main pathology changes, fibrous cells begin to increase, form fibrous scar, organize, some cardiac muscle can have hyperplasia, loose, in focus but calcification and cardiac dilatation, membrane increase thick enclosing the intersection of wall and thrombosis,etc. in the heart. At acute or chronic stage, myocarditis can involve the heart and conduct the system, cause block or various arrhythmia. No matter it is substantive myocarditis or among quality myocarditis,too will cause at various degrees cardiac muscle not to be soft and unable, the heart function happens to detract.
The first stage virus duplicates the issue, this stage is that virus infringes the cardiac muscle directly by the blood, the virus acts on directly, the myocardium cell dissolution emerges. Abnormal reaction period of the immunity of the second stage. As to most viral myocarditis (especially chronic one person) ,The virus may not exist yet within this period, but the cardiac muscle is still damaged continuously. Think this pathogenesis is through the immune allergy, mainly T cell immunity damages and causes a disease at present.
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