's general knowledge of viral hepatitis C

's general knowledge of viral hepatitis C
Hepatitis C is infected by HCV, HCV was 1989 by U.S.A. Choo,etc. from the chimpanzee blood sample that was infected, only find one while cloning positively to clone from 1 million, is named as the C-mode hepatitis virus, hepatitis C mainly from blood /humoral to last 70% of hepatitis behind blood transfusion. Persons who carries HCV are less than person who carries HBV in our country, it is 0.7% - 3.1% to resist HCV positive rate in the healthy crowd, characteristic of this disease: 1)Acute hepatitis symptom is relatively light, it is relatively light to often have no jaundice or jaundice, the jaundice patient only accounts for 25%. 2)The high intensity of melting that chronic, 50% of the acute hepatitis is apt to develop into chronic hepatitis. 3)Some case infect with with the intersection of HBV and overlap, have more simple symptoms relatively HCV infect heavily often. Adopt, unite interferon with the intersection of virus and the intersection of thiazole and treatment for more effective therapeutic method at present.
C-mode hepatitis virus (HCV)
After calling blood transfusion in the past or the humoral transmitting type was not that A was not a B-mode hepatitis virus. Choo,etc. set up cDNA library from the chimpanzee blood sample that was infected in 1989, find, clone with copies of the intersection of disease and convalescent the intersection of serum and whom a masculine gender give by one clone, from 1 million of moon (5-1-1) ,Named as HCV.
Array analysis compares, HCV is very similar to yellow virus, genetic structure of acute communicable diseases and virus, therefore include in yellow virus (Flavivirus) Department's C-mode hepatitis virus' genus. Preliminary research show, in electric mirror being the intersection of 55nm and spherical particle of diameter in lower HCV, go bag the intersection of 33nm and nuclear the intersection of shell and key part that albumen include of diameter behind the membrane, include the single burst of straight chain RNA genome of about 9400 pieces of nucleotide of the total length. Both sides of genome, respectively for 5 ' and 3 ' not encoding area. Code why albumen (C) sequentially from 5 ' end it will be district District, making the membrane albumen (E) District and it is not the structure (NS) District. The latter is divided into districts such as NS1, NS2, NS3, NS4, NS5,etc. again. NS1 is also called E2/NS1. The nuclear shell albumen of genetic code of structure of C district, E1, E2/NS2 district code charter the glycoprotein of membrane. NS3, NS4, NS5 district encode non- structural protein of different functions respectively.
According to the array homology intensity of nucleotide, can divide HCV into several genotypes and inferior type. If Simmonds is divided into 6 (1-6) Type
It is inferior type to divide into several more as follows. Mori/Okomoto is divided into 6 (1-4) simply Type without inferior type. It is obviously regional that the genotype is distributed. The North of China's Mainland is with 2a(3) Type main fact,the South with 1b(2) Type for main fact,6a discovery only at Hong Kong.
HCV is to be changeable different,in and type every among,even difference also between not cloning as a patient of what periods different separates. The difference of the gene sequence, will result in encoding the difference of the antigen type of products. There are actual meanings in preparing reagent.
Its mechanism that happens of hepatitis C, still indeterminate at present. But experiment research shows: The liver of hepatitis C sick position has most monocytes that are soaked, inflammation and necrosis take place, this is similar to liver pathological change that HBV cause. Meanwhile, infect behind the HCV, too is as HBV infects apt to take place chronic hepatitis, liver cirrhosis and hepatocarcinoma. This proves, HCV infects liver pathological change caused and infects with HBV similarly too, it causes the immunity to the hepatocyte to damage to mainly bring out human immunoreaction by the virus. And already undoubtedly confirmed through the spread transfusing blood and employing the blood products to cause. In addition, acupuncture, abusing and injecting medicines, tattooing, excrement route, mother and baby of going back spread vertically, and levels such as saliva, droplets, kissing and sex contact,etc. spread, it is the possible reason for causing hepatitis C.
So, all the person who accepts blood transfusion and blood products; Inject (especially intravenous injection) , drug addict, blood dialysis and kidney is transplanted to patients; Persons who keep in touch in hepatitis C family, especially spouse; The person who has improper sexual behavior or homosexuality, it is a sense crowd. In addition, medical worker, staff member, person who deals with blood or blood products in the laboratory, the morbidity of its third liver is relatively high too.
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