The gene mutation of virus initiates _'s general knowledge of hepatocarcinoma

The gene mutation of virus initiates _'s general knowledge of hepatocarcinoma
Near, a research shows: The key gene of hepatitis B starts a pair of mutation of son to relate to emergence of the primary hepatocarcinoma in Guangxi.

This question is " case controlled study of the virus gene mutation of hepatitis B and relation of hepatocarcinoma of Guangxi ", it is under the guidance of brightness of village of academician of Chinese Academy of Sciences, by what Center for Disease Prevention and Control of Guangxi studies, it is a key scientific research project of department of public health of Guangxi. Guangxi global primary the intersection of hepatocarcinoma and high person who take place one of, chronic hepatitis B it infects with to be main dangerous factor of hepatocarcinoma, different hepatitis B make a variation have a different one to be pathogenic, study virus, make a variation a relation with hepatocarcinoma, very important for hepatocarcinoma prevention and control of Guangxi.

The seminar lasted 3 years from December of 2000 to February of 2003, according to the controlled study method of the case, adopt the technology of molecular biology to amplify to person who carries virus of all kinds of hepatitis B of Guangxi and check order to analyze HBVDNA. Meanwhile, start the intersection of son and pairs of mutation and relevant relation, Guangxi of hepatocarcinoma, analyze to the intersection of HBV and key gene still, the result shows: There is not relevant relation between mutation of C district and primary hepatocarcinoma of Guangxi ago HBV; HBV gene starts a pair of mutation of son and HBeAg there is not relevant relation; It is closely related to primary hepatocarcinoma that HBV key gene starts a pair of mutation of son, relatively dangerous degree is 36.9. This result shows: In Guangxi, HBV infect with primary relevant relation of hepatocarcinoma, it is the intersection of HBV and key gene that start the intersection of son and pairs of mutation and primary relation of hepatocarcinoma mainly. So, HBV key gene starts a pair of mutation of son and can be regarded as hepatocarcinoma and endangered one of the indexes high, thus make the intersection of hepatocarcinoma and high-risk group sift, check, work, raise the efficiency further.
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