Which are the daily medicine to treat ulcer colitis at present? 's general knowledge

Which are the daily medicine to treat ulcer colitis at present? 's general knowledge
ACTH, adrenocortical hormone and sulfa drug, in order to control the most effective medicine of a disease at present. (1)Adrenocortical hormone and ACTH: Suitable for acute one and serious case of colon with extensive pathological change, daily ACTH20-40 units add the vein into 5% glucose solution 500ml to instil (finish dripping in about 8 hours) ,Or hypodermic injection of 80- 1000 units of ACTH emulsion; Cortisone 100- 300mg of daily hydrogenation adds the vein into 5% glucose solution 500ml to instil slowly, it is usually a course of treatment, oral prednisone or Meticortelone 20- 80mg/d in 2 weeks. Unless through being the above-mentioned dosage treatment, it make behind curative effects satisfactory,should decrement gradually,to keeping amount at, very every morning or the next day one, generally take prednisone. Treat pathological change disappear totally or basically, then decrement up to inactive gradually within 1- 3 months. Cause the bad reaction in order to avoid employing the adrenocortical hormone all over for a long time, limited to the rectum and second form colon more light case that carries to pathological change far, but the part gives medicine. Light the intersection of disease and case and case, descending colon of pathological change, can adopt parenteral the intersection of amber and sour the intersection of sodium and the intersection of hydrogenation and the intersection of cortisone and 100mg or parenteral Meticortelone 20mg add the physiological saline, keep enema, sleep the first once, the symptom changes into every week 2-3 times after controlling, course of treatment is 1- 3 months. The foreign report treats and carries colitis far with this law, it is 75% to be efficient; Use hormone or add traditional Chinese medicine enema at home, curative effect is improved to some extent. The case of the rectum with serious pathological change can be adopted and included antibacterial medicine suppository which hydrogenate loose 10mg doing in the test, include in the rectum, one each time two times a day; Can also make enema treatment, but rectum convulsion incident, difficult to keep, can add Procaine in medicinal solution, or help medicinal solution to keep with the foaming agent of glucocorticoid. (2)Anti-infectious medicine: Nitrogen sulfanilamide pyridine (SASP) of the first-selected willow ,The therapeutic mechanism of this medicine, is mainly resolved into sulfanilamide pyridine (SP) by the colon bacterium after taking orally With 5 - amino salicylic acid (5 - SAS) ,The former discharges from urine after absorbing the supersession again, but the latter plays a antiinfectious role in the intestine, this medicine can be lightened and broken out and reduces and break out, is relatively suitable for chronic one. Slightly, on issues of daily 4- 6g of breaking out, divide into, take orally by 4 times, the condition changes into daily 2g after relieving by intermediate patient, divide and take orally twice, use for 1- 2 years. According to thinking it is 6- 24 months during the best curative effect, so use and need to reappraise curative effect promptly two years later longest. This medicine is efficient and generally above 80% to treatment of this disease. During taking medicine, the bad reaction of this medicine is disgusting and vomiting, having a headache, cause a cell to reduce disease, drug rash and produce the seminal fluid unusual and causing sterility once in a while. The side effect relates to medicine amount, quantity 4g the above one of daily expenses, the side effect increases notably. Already even nitrogen benzoic acid, even two sodium nitrogen salicylic acid of new medicine such as salicylic acid,etc. come out at present, they can save effective composition 5 amino salicylic acid (5 - S AS) of SASP ,And reduce the side reaction of SASP, the long-term consumption average daily 1.8g of these medicines. In addition, there is directly oral 5 - S AS preparation now, because absorb and play a role in treating colon and ulcer in the small intestine, can employ 5 - SAS 2- 4g to put in right amount of solutions, adds adrenocortical hormone enema, 1 times a day, it is a course of treatment in 2 weeks, repeatable if necessary. The patient allergic to sulfanilamide, very daily oral ammonia benzyl penicillin 2- 4g, or ammonia benzyl 2- 4g of very beginning spore. Find copies of disease have a certain in the intestines of patient in recent years (or some) Reproduction of anaerobe, sometimes, in the intersection of activity and issues of excrement of patient, can detect difficult to distinguish fusiform ectotoxin of bacillus, and the latter can aggravate pathological change and symptom, as to such conditions, can adopt first nitre thiazole (metronidazole) Or mould plain oral administration comes to control symptom through the ages. (3)Immune inhibitor: To the sulfa drug or case that the adrenocortical hormone fails to respond to any medical treatment, someone maintains that uses instead or adds and uses other immune inhibitors, such as sulphur thiazole purine or 6 - sulfhydryl- base purine, the dosage is calculated according to daily 1.5mg/kg. But this kind of medicine toxicity is great, there are many side effects, especially the inhibition of the bone marrow, so when it use must cautious,course should check by blood regularly after using medicine like,last blood the changes of the leucocytes tightly, as the leucocyte number is reduced to 5* 109/Under L, should be reduced by half and taken, the leucocyte number is reduced to 3* 109/Should stop medicines under L person. The general course of treatment, from half a year to 2. These medicines have not confirmed yet to the curative effect of this disease, also indicate in animal's model that there is carcinogenic function, so, this kind of medicine is not a medicine used conventionally, only under other situations of failing to respond to any medical treatment, just have value used.
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