Which kinds of _s test the inspection there is vaccine of hepatitis B at present

Which kinds of _s test the inspection there is vaccine of hepatitis B at present
Vaccine of hepatitis B that employ mainly have the following aspects on being at present clinical:
(1)Source vaccine of hepatitis B of blood: This vaccine is by having no blood of the person who carries HBsAg of symptom to make, so call source vaccine of hepatitis B of blood. Its preparation step is roughly: Adopt high to drip degrees of the intersection of HBsAg and positive blood of carrying etc., separate the intersection of bleeding and thick liquid and remove, have HBV that infect behind the particle it, and then concentrate HBsAg and purification, deactivate fully, in order to eliminate all known virus that it may exist and dispel the intersection of HBsAg and all the intersection of host and albumen that surface might exist, then added adjuvant and preservative. In order to ensure the safety of vaccine, every stages take a sample and do testing aseptically, heat source testing and animal to test etc. safely, whether there is antigenic material in other pathogen and blood in vaccine in order to check. The immunity of this kind of vaccine has already with security solve been originallied, but still there are some shortcomings: In order to prevent some pathogen that may exist from escaping deactivating in the course of preparing, have adopted the strict, complicated and time-consuming physics and purified HBsAg antigen of chemical method and deactivated the measure, make, prepare cost raise and vaccine output high; With the extensive use for a long time of vaccine of hepatitis B, there is not symptom HBsAg the number carried certainly will be reduced gradually, difficult by and then preparing vaccine with their blood finally.
(2)Vaccine of genetic engineering: Utilize genetic engineering to develop and recombinate DNA hepatitis B vaccine, had successively developed Escherichia coli system, beer yeast cell system, mammalian cell system and recombination hepatitis B vaccine of the smallpox pupstule virus system. Recombination vaccine of the multi-purpose yeast gene at present. It is original that it has good immunity, it is basically similar that the immunity replies source vaccine of hepatitis B of characteristic and blood, and does not have more serious bad reactions. Though it sucks the yeast albumen and does not exceed 1%, the worry that it produce allergy has not been totally got rid of yet.
(3)Hepatitis B vaccine of S albumen before includesing: Blood source nature vaccine and genetic engineering vaccine that employ, only HBsAg albumen is sucked on being at present clinical, , vaccine containing HBsAg albumen dialyses the immune result of patient and neonate to the blood to notice again it is only simple when being worse, then produce source hepatitis B vaccine of recombination of yeast of S albumen before adding, it can really strengthen the immunity to reply obviously.
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