Skin cells " L Breed " R Three generations' little living mouse appears

Skin cells " L Breed " R Three generations' little living mouse appears
(chief correspondent Ren Quan) Besides embryo's stem cell, the life has the second " L The all-round seed " R (used at the end of a question)? Recently, one is " L It is small " Lasting scientist definite answer. Because it is not parents " L Crystallization of love " ,Not also a scientist meticulously " L Model " R Clone by mouse,it is but black from each skin cell of mouse, pass " L Programme again " R And then iPS cells (induce the multi-functional stem cell) got " L Pregnant with " R Little life.
Yesterday, international authority's academic magazine>Have reported online " L It is small " R Extraordinary for life experience,organize also specially one of news briefing,last Chinese the the research resultses of the scientists a in the world more than 30 medias importants.
It is introducedded, in the past several years, the research groups of fine jade researcher and once all researcher's leadership of Shanghai Communications University medical college of week of research institute of animal of Chinese Academy of Sciences, utilize iPS cells to successively breed out 27 pieces of resembling " L It is small " R Black for mouse,thus in the world it is first identification,iPS be had one that similar to embryo's stem cell who is all-round cell, it becomes an intact life entity that can be developmental.
Known as " L All-round player " Embryo stem cell for mankind mend hope of organ of,but in source and ethics enormous to challenge. Make into body cells and programme iPS cells got again by way of inducing manually, because have multi-functional characteristic similar to embryo's stem cell, and can have wound the forbidden zone of ethics, become the international focus of stem-cell research in recent years rapidly.
But," L The pleuripotent " R Do not represent after all " L All-round " ,If can prove iPS cells like embryo's stem cell " Omnipotent " ,Will make its application prospect broader. For this reason, determine cell have getting all-round according to scientific circles (could develop, succeed intravital animal) (used after an attribute) " L The gold standard " ,The scientists of various countries are repeating the experiment constantly, explore hard, but all the time nobody has succeeded.
Finally, the firm and indomitable Chinese scientist has this luck. They at first black skin cell of mouse" L Reverse " R It is iPS cells, construct 37 iPS cells independently; Then inject iPS cells of 6 among them into 1500 multiple tetraploidy blastaeas separately, and then plant into a group of uteruses which takes the place of the pregnant white mouse; 21 days later, " L It is small " R Born miraculously. So far, " L It is small " R Have already grown for more than 9 months healthily, follow 26 behind it " L Younger brother " , " Younger sister " .
Through the technical appraisement of many kinds of molecular biology, these 27 black mice really come from iPS cell development. They become the first batch of little mice of living subject totally formed after iPS cells are pregnant with in the world from this, have proved effectively iPS cells have a real one " L All-round " .
Nowadays, " L It is small " R The family may be said " L Have a growing family " . Under the circumstances that researchers' skillful heart arranges, the breeding that 27 black mice successively succeeded with ordinary white mouse, grow and lay second of several hundred and little the third generation of mouse successively . " L Mouse's father " R Promoted as " L Mouse's grandfather " ,Have crossed " L Descendants stay with one's parents in order to make them happy " R Happy life," L Continue " Burn the intersection of Chinese and scientist in the intersection of stem cell and international hot great innovation of research field this.
Why use the tetraploidy bag embryo if it is chained that relevant?
Usually, the chromosome of the little normal mouse is the double body. Tetraploidy blastaea plant into behind the uterus, unable to continue development natural death. So, are pregnant with " L It is small " R Course in,tetraploidy blastaea only act" L The hotbed " R Role,is it responsible to offer appropriate development environment for iPS cell. And if adopt the normal double body blastaea, will breed the body of gomphosis formed after iPS cells are merged with the blastaea out, this will be unable to prove whether the new life comes from iPS cells.
IPS cell global study the significant events
Stretched and filled the research group to induce little mouse's skin cells as the stem cell (namely iPS cells) in the Japanese mountain in August of 2006 .
In November of 2007 American and Japanese scientist claim respectively to find independently, can turn human skin cells into iPS cells.
In December of 2007 the scientist of American Whitehead biomedical research institute finds usable iPS cells treat the little mouse of of blood of cell of sickle.
In July of 2009 the Chinese scientist verify iPS cells have development ability similar to embryo's stem cell.
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