Why is not the cancer cell afraid of chemotherapy?

Why is not the cancer cell afraid of chemotherapy?
Drug therapy of applied chemistry (abbreviated as chemotherapy) Cancer, deal with one of the important methods of cancer on being clinical at present. However, chemotherapy cures cancer and does not wish with people. Though up to several dozen of anticancer drug, having the amount of kind 20 commonly used, although give cancer cell of many kinds of malignant tumour the blow at various degrees, but can not eliminate it, even increase medicine consumption, it is difficult to inhibit the devilish procreation descendants of cancer cell, make cancer must take place, shift, use medicine at the same time much dosage large, increase toxicity react, and lethal danger. This has become clinician's extremely troublesome question. Why is not the cancer cell afraid of chemotherapy? We can say to able to bear nature (commonly called as drug resistance) cancer cell Mechanism intricate, until but nature study and show at present for cancer cell, the cancer cell may be said cunningly that changeable, there are all sorts of " magic weapons " of dealing with the chemotherapy medicine . Anticancer drug in the face of coming of some cancer cells, its cell membrane will change, make anticancer drugs take in and reduce and excrete and increase, make the medicine density insufficient in this way, lead to the fact curative effect drops or invalid; After some cancer cells are attacked by the anticancer drugs, the damage that can cause rapidly is repaired; Some cancer cells are good at destroying the medicine attacked, make anticancer drugs lose fighting capacity; Still the content of topological isomerase 2 included of some cancer cells is reduced, the activity is reduced, insensitive to medicine, thus make anticancer drugs bemoan in the face of cancer. The scientist finds, P - glycoprotein in the human body distributes on the cell membrane of tissue cells such as brain blo od vessel, renal gland, lung, liver, kidney, small intestine, colon, pancre as,etc. ex tensively, in normal cases, it looks like " water pump " Seek kind, discharge the wastes of supersession of these internal organs outside cells, safeguard the organism to be healthy. But P - glycoprotein go, serve for the cancer cell like normal cell of protection even, it will strengthen the line of defence of cancer cell to make the cell membrane tough and tensile, has not merely hindered anticancer drugs from entering in the cancer cell smoothly, and discharge the medicine already entered rapidly, make anticancer drugs unable to produce and wound function and cause chemotherapy to fail. In the face of to able to bear nature cancer cell, domestic the intersection of pharmacy and house of place work out all sorts of methods to deal with, for example carrying on anticancer drug " Pack " ,In order to lighten the bad response, strengthen curative effect. The first-selected medicine to treat gastric carcinoma is 5 - Fluorine urea pyrimidine, but because poisonous side reaction is great, curative effect is unsatisfactory, make a lot of cancer patients unwilling to accept chemotherapy. Through " pack " And then Fluorine 5 dense in urea for pyridine,last " the suit of armour " body , This it is many kinds of the intersection of Fluorine and the intersection of urea and the intersecti on of pyrimidine and heterogeneous the intersection of lipoprotein and body that radiate liquid, give medicine quantity only 5 - the intersection of Fluorine and the intersection of urea and dense 1/4- 1/3 of pyridine, distribution amount in the body 7.7 times that of 5- Fluorine urea dense pyridine in the intersection of cancer and tumour, one that is to gastric carcinoma efficient to rise to 42-76% from 20% original, give anticancer drug " Wear " Have " disguise " ,Can reach the target region rapidly, annihilate the cancer cell. For instance A is mould anticancer drugs such as plain, mitomycin pass specially " Pack " ,This kind change, already can enable cance r cell because of the ischemic d eath by right one new medicine. Can maintain the lethality of more th an two weeks, evident effect. The scientists adopt the integration technology of cell, merge to hybridize tumour cells immune lymphocytes with tumour cells, pass the cloning one again, become and clone only, monoclonal antibody that it can secrete the high purity, very strong attractive to the cancer cell, let it carry anticancer drugs, it is a far-famed " biological guided missile " ,Can penetrate cancer and organize forbidding the slightest violation of the people's interests with c ells quickly behind entering the human body. The living beings of medicine institute Chinese Academy of Sciences, Shijiazhuang developed " Igy-RA " ,Kill cancer cell specially, wait for later period malignant tumour under digestive tract to cancer of the esophagus, cardia cancer, gastric carcinoma, it is up to 76% that always efficient. The physicians are still in clinical scientific research, reversible cancer cell but medicine of nature such as finding rice of Vera's handkerchief, nitre benzene pyridine, erythromycin, reserpine, ring spore's fungus are plain, hydrogenation cortisone, while carrying on chemotherapy for patients, select for use according to situation, can strengthen the curative effect against cancer medicine. According to Wuhan TV station, a leukemia patient passes chemotherapy of 2 courses of treatment, make anticancer drugs not work because of producing and is able to bear nature, and then add and surround a plain course of treatment of spore's fungus with immune inhibitor, just make able to bear the level when the medicine density in the cancer cell of medicine is returned to sensitively, thus make the acute condition of one relieved. Anticancer drugs such as employing A to be mould and plain, new alkali of Changchun treat bladder cancer, after adding and using rice of Vera's handkerchief, can inhibit many medicines of the bladder from being able to bear nature, while can stren gthen the sensitiveness that the cancer cel l oppose cancer medicine, improve curative effect. Ocean network

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