How many kinds does the therapeutic method of leukemia have

How many kinds does the therapeutic method of leukemia have
Guo Hui is lucky, repelling after swarming into and transplanting at last and the infection was closed, went out of the aseptic cabin isolated with the external world, become 307 hospitals of successful leukemia patients of first bone-marrow transplantation in new century of PLA man. King's recruited president feels a sincere one is gratified, because in the 307 hospitals of bone marrow transplant centres, the luck person like Guo Hui has already had more than 380 so far, their life all set sail to set sail from here again. 1 the intersection of body and the intersection of bone-marrow transplantation and leukemia commonly called as the intersection of blood and cancer since, it is the intersection of tumour and the intersection of cell and malignant hyperplasia that influence normal hematopoietic function and a kind of malignant cancer of immunological function. It is reported, the number of the infected of the annual leukemia in the whole world is up to more than 300,000, probably 3 to 40,000 people suffer from leukemia newly every year in our country, and between twenty and fifty accounts for more than 80%, among them most persons are seized the life by the merciless serious illness. In 1986, 307 hospitals of PLA man succeeded in launching from the bone-marrow transplantation of body. That one 22 -year-old the intersection of company and woman staff member, have a high fever suddenly, nostril bleed, diagnosed as acute lymphocyte leukemia. The medical workers of 307 hospitals of bone marrow transplant teams have implemented him from the bone-marrow transplantation of body. This kind of transplantation method is, the doctor takes the bone marrow in patient's body out to deal with first, go on all over heavy dose of set to patient free, chemotherapy thereafter, kill the cancer cell in the body, and then defeated by the patient the bone marrow taken out in the body, and is breeding hyperplasia constantly. At this moment, the patient moves in " spotlessly" Aseptic for cabin,the whole without being implemented for environmental protection's and be attended to specially. 49 days after transplanting, the patient's bone marrow, blood are like resuming gradually, reach the normal person's level one month later. 2 different genetic bone-marrow transplantation bone-marrow transplantation is really used for treating leukemia, it is domestic the first thing coming from happening after the foundation of the state that radiates the accident seriously. At the end of November of 1963, 60 radioactive source " missing "s of cobalt of Anhui agricultural college (used after a verb to indicate the completion of an action). A local young peasant called Ge ChuanFu has found a pig sealed by the pond. Out of curiosity, he fiddles with, has seen some the pig there is a shiny metal piece inside, it thinks to be by mistake" The treasure " ,Carry and enter the pocket and run and come back home to hit right away. In the afternoon, he begins to be sick and vomiting without end. That night and the clothing, elder brother, younger brother sleep together. At night, uncle come Ge handle affairs and stay. Getting up by next morning, he is shone by the more than 9 hours altogether. Two days later, Ge ChuanFu falling ill remembers the metal piece installed in the pocket. The unfortunate thing has taken place again and again, the younger brother takes advantage of the sick elder brother to be careless, fill the metal piece into one's own trousers bag secretly. In the evening, mother and the young son and daughter of illness sleep together. , other 4 people receive 212 hours -long heavy dose and shine, the life hangs by a hair. Villagers have sent the patient to 307 hospitals of PLA man. Though the hospital attacks radiation sickness mainly, has not really accepted for medical treatment and radiated patients in the same way yet after all. Take on, treat and cure group leader, our country, engaged in the intersection of radiation sickness and the intersection of leaf and root of research shine Professor first, radiate patients and implement bone-marrow transplantation and comprehensive treatment means and succeed to 4, patient's healthy life as normal people so far, has created the miracle of radiation sickness treatment. Success of this group of radiation sickness is rescued, make Professor Ye and medical worker transfer the eyes to treatment of leukemia, seem to see the dream for many years is expected to become reality. Hereafter, the root of the leaf shone the professor began to explore that utilizes treating the experience of radiation sickness, expand to, treat at the leukemia, carry on, shine while being heavy dose of to the intersection of leukemia and patient, make the patient cause acute radiation sickness artificially, convert leukemia people to acutely to radiate patients, then according to existing to treat acute the intersection of infusion and the intersection of health and bone marrow,etc. of radiation sickness, succeed in the method treat acute radiation sickness. In 1980, they used the regenerated obstacle blood disease patient of anaemia,etc. of this kind of method treatment. At this time, the bone-marrow transplantation in the world is developed very fast. Professor Ye causes the high concern in the international counterpart because succeed in treating and curing 4 cases of radiation sickness patient, participate in international academic meeting and joint study on invitation many times, has understood and known foreign bone-marrow transplantation advanced technology. Soon, 307 hospitals have set up first HLA laboratory of our country and two clean wards, the former is for cooperating with the mixing type of bone-marrow transplantation to study, that is to prove whether it is totally identical to support the human leucocyte antigen between the persons who receive; The latter supports patients to transplant and move in, implement the protective segregation, so as not to infect. After one year, their university student with acute leukemia implemented different genetic bone-marrow transplantation. Until body a different one since, different genetic bone-marrow transplantation to infuse get patient in the body others' bone marrow, will be put chemotherapy to all destroy through being heavy dose of by the bone marrow of morbid state person, will infuse the bone marrow of person who supports health that HLA mixing type will be made up to the persons who receive, make it in person regenerate, rebuild hematopoiesis and immunological function of person who receive in the body. Fortunately, patients are identical with the elder brother's bone marrow. One month later, the elder brother's bone marrow survives in younger brother's body, the hematopoietic function can resume. It was once the generally acknowledged best method in the world that 3 peripheral blood stem cells transplanted bone-marrow transplantation and treated leukemia, but the precondition is the bone marrow collecting the persons who are supported. In 1995, it has been rewritten that this kind released law of bone-marrow transplantation to be gone to France director Chen Hu and his assistants returning after finishing study. In June of 1995, a Beijing patient went to 307 hospitals to ask and manage, the expert diagnosed as chronic leukemia, need the bone marrow transfer operation of conduct. But the person who supports marrow conforming to patient's mixing type is unwilling to let the doctor smoke the marrow. Director Chen's flat decision, release its peripheral blood to transplant the stem cell. The persons who support agree in this way. But law this have precedent is yet starting stage in in the world yet at home at that time. In November of 1995, the doctors collected peripheral blood twice and isolated 100 ml of stem cell from the persons who supported in the body together, then input into patient's body. More than months cure and attend to meticulously through one, the patient recovers and leaves hospital. This is an unusual surgery, it is a great breakthrough that our country treats leukemia. It transplanted and substituted and collected history of the bone marrow in the past with the peripheral blood stem cell of allosome, only need to isolate about 100 ml of blood with hematopoietic stem cell to transplant from the persons who support in the body, as to the method to collect bone marrow, this person who supports law has no agony, patient's leucocyte is fast-growing, and complications of different infection of persons who can inhibit the future trouble of past bone-marrow transplantation. This new technology is appraised as ten major science and technology news of Chinese medicine of 1996, become first-selected methods to generally adopt both at home and abroad at present. So far, 307 hospitals The bone-marrow transplantation centre has already finished the peripheral blood stem cell of different gene and transplanted more than 100, success rate occupies the domestic forefront, remain the domestic leading position all the time in this field. Half 4 HLA coincide, transplant bone-marrow transplantation have 3 method at present, support the identical twin " genetic bone-marrow transplantation " of marrow ; Second, " bone marrow transplant since physically " ; Third, " different genetic bone marrow transplant " . " and genetic bone marrow transplant " Situation few,in and that adopt usually since transplant body and transplant allosome. By the look of result, the allosome is transplanted and obviously superior to since the body is transplanted, the new students in body of the patient are the healthy " new host " ,It is difficult to recur. Weigh from the indication and curative effect two respects, all first elect the allosome to transplant. But a serious one, allosome transplant demand, choose with the intersection of patient and the intersection of leucocyte and person who supports marrow that antigen at all coincide, have 1/4 hope only even the compatriot siblings, in look for in the relative being 1/30 Wan in probability, really look for a needle in a haystack. Because the double restrictions of mixing type and economic condition, can transplant to only 1% of patient who obtain life. The more troubling one is, our country has already entered only-child times, the miniaturization day by day of the family, leukemia occur frequently on teenagers again, can only in look for the person who supports marrow in the relative, and registers only thousands of of number of people at present, and lack the fund in the bone marrow storehouse of our country, not running effectively formally yet, this road is obviously difficult to go down. , open up the path and treat leukemia and just become the domestic and foreign scholar's generally paying close attention to and subject to be solved urgently separately. 1994, foreign scholar propose and begin, implement half HLA coincide and transplant. 307 hospital the intersection of bone-marrow transplantation and department aim at international medical front tightly, catch, coincide, transplant as target of tackling key problems by half HLA, and succeeded. Beautiful roc, a little boy in 12 -year-old Guangdong, had illness coming on in March of 1994, diagnosed as acute lymphocyte leukemia. In December of 1998, the little beautiful roc came to 307 hospitals of bone-marrow transplantation departments in the company of father, the medical worker decides to transplant its father's bone marrow for him. On January 22, 1999, doctors divided it twice to gather peripheral blood from its father, input in the little beautiful roc's body after special-purpose processing. The 13th day after transplanting, the leucocyte in the his blood is counted and risen to every cube millimetre more than 1000, the blood platelet number rises to every cube millimetre more than 20,000. But begin to drop 20 days later. The medical worker decides to infuse the bone marrow and hematopoietic stem cell of peripheral blood for him again. 14 days later, his hematopoietic function is rebuilt. Leucocyte and blood platelet number are returned to normal standards of people one month later. 100 days after transplanting, for verifying the bone marrow is planted into success by DNA fingerprint atlas person. Nowadays, the little beautiful roc shoulders the schoolbag again, and the same as age child, sit and listen to teacher in the bright classroom. Half HLA coincide and transplant succeeding in making more leukemia patients have hope cured, patient so long as parents right away may accept treatment this while being alive. Siblings of patient compatriot HLA can reach 50% instead of half probability that coincides, it is far much higher than the probability that is totally coincided, this, to leukemia patient, it is undoubtedly a good news. 5 the intersection of magnetization and cell separate technology because of a great deal of reason, can go on, it transplants treats to be still minority. Director Chen Hu says, only depends on scientific and technical innovation, is expanding the new means to treat leukemia constantly, could bring the hope for more leukemia patients. In February of 1999, the first of our country accepted magnetization cells and separated the patient that the new technology was transplanted, transplant the centre in 307 hospitals and recover to leave hospital. According to the method in the past, can only implement and transplant from the peripheral blood stem cell of body the occuring frequently tumour patient of bone marrow. The deficiency of this method is, though deal with chemotherapy to the patient before the skill, but implant inside and still retain a few tumour cells, it is unable to reject it clean, go back, fail, get patient have potential recurring possible in the body again so. This time, medical worker separates for drawing to the cells that the patient failed through purifying, do not have tumour cells and the incidental. This was too unimaginable to be accomplished either in the past. Accomplish this point, need clinical grade of magnetization cells to sort the system. It according to good and bad to go on, screen peripheral blood of patient, reject among them the intersection of tumour and cell and incidental, and then lose the high and purified stem cell got from this in patient's body, in this way, will reduce the condition to the greatest extent and recur, the quality of improving patients and surviving. To high problem of recuring etc. since the body is transplanted, before the 5 year, they adopt outside the body amplifying, dashing for ward the written complaint, defeating by France the intersection of body and tree in the world for the first time, have solved this difficult problem that leukemia has recured since the body is transplanted effectively, has already transplanted more than 40 so far. And then has launched transplanting, CD34 positive cell transplanting, adult's umbilicus blood of persons who support of having nothing to do to transplant etc. at home again, become entire PLA first cells and genetic rescue centers. Nowadays, they can transplant the procedure to the hematopoietic stem cell, namely different periods input the doing and hindering cells of different functions. These cells are dealt with outside the body effectively in advance, thus reduce the side effect. This off-the-shelf kind of method has already been expanded to the treatment of other tumour number. Nowadays, it is no longer the single bone-marrow transplantation of the past to treat leukemia, but according to the patient's one's own situation, take many kinds of methods to cure. Until the intersection of body and bone-marrow transplantation, different genetic bone-marrow transplantation, peripheral the intersection of blood and stem cell transplant to half HLA coincide, transplant and the intersection of magnetization and cell separate technology,etc. since, leukemia is being conquered constantly, the leukemia patient is seeing the dawn of the life from it constantly too.

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