Have already proved _ general knowledge of the genetic relation with colitis in the white race

Have already proved _ general knowledge of the genetic relation with colitis in the white race
Gene mutation is very common in the ulcer colitis patient, a new research offered more evidences for this argument recently. But this result of study reveals, disease at ulcer colitis of gene mutation seems while developing that has not played any function.
The scientists have already found many kinds of gene and ulcer colitis ' It causes ulcer to take shape and bleed that the immune system damages the intestines wall of large intestine) Have something to do. Focal point of research this those in cell factor ' Chemical material of interaction between the immune cells of a kind of participation) Production course that China contribute gene.
M of the royal Hallamshire hospital of Britain. J. Dr. Carter, to according with a gene of the above-mentioned condition - -The leucocyte is lain between plainly - a receptor short of money variation situation against pharmaceutical carries on research. First report about this gene the intersection of variation and body ' Abbreviated as allele 2) The relation with ulcer colitis was in 1994. Though ulcer the intersection of colitis and research of patient verify existence of relation this already in the descendant to Jew and Spaniard, but not had final conclusion yet in the North European philtrum.
Research this include 320 ulcer the intersection of colitis and patient and 827 healthy people ' It is descendants of Nordics) . Carter finds, the possibility to carry the genetic mutant in the colitis patient is higher. The appearance proportion of this gene is 45% in healthy people, this proportion is 52% in the colitis patient. Excise in the patient of colon already for treat disease this in the whole the intersection of colitis and disease of suffering from, gene mutation and ulcer relation of colitis more prominent ' Relevance is 56% and 55%) respectively . It is with this genetic mutant ulcer will appear to patient possibility of colitises than as people take so high 30%.
Past finding, allele 2 appearance and one the intersection of large intestine and intestines known as in the wall leucocyte lie between plain and 1 receptor resist protein (IL-1ra) while being short of money Cell getting lower in that factor level is relevant,think Carter and their colleague play a role in suring the cell factor in the course of controlling the inflammation. But researchers find, the mutation of this gene takes place in the not encoding area, will not produce any influence on protein produced by this gene.
David van Heel of human science of heredity of Oxford University says to reporters: "This kind of mutant seems not to bring about any change in function of the gene, it may close to sudden change one ' Perhaps happen on another gene) Things tagged,but this yet confirmation. "
In addition, van Heel thinks, the test design of this research is apt to cause the false positive result, because the slight, difference not realized exists between ulcer colitis patient and contrast person, such as ethnic group's background, it is much too early so make the sure conclusion now, further research is very essential.
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