Which are the pathogenic factor of vitiligo?

Which are the pathogenic factor of vitiligo?

A lot of friend incoming telegrams inquire me littly and compile, which are the reason why vitiligo has illness coming on? We want to know the pathologic characteristic of vitiligo first before thinking that finds out the pathogenic factor of vitiligo. Vitiligo is that the morbidity is high, easy to diagnose, skin disease difficult to cure. The expert points out, the clinical treatment proves that treating vitiligo adheres to the therapeutic principle early, accept the regular treatment on the initial stage of having illness coming on. Then which are the pathogenic factor of vitiligo? And then the expert analyzes one by one for everybody.
1.Black plain cells are destroyed (self-destruction of melanocytes) The basic pathological change of theory vitiligo is the black plain cell part of epidermis or totally loses the function. Lerner1971 proposes this theory every year. Think vitiligo is to decline in early days because of their epidermis black plain cell hyperfunction, the consume urged, and may be because synthetic black plain predecessor material of toxicity of cell is gathered. The experiment proves some chemical materials have alternative katogene on black plain cell, make the skin decolorize, these materials belong to more decolourization pharmaceuticals which replace the phenol type chemical material, for instance hydrogen quinone form benzene ether, hydrogen quinone, chat phenol of cube, hydrogen peroxide solution etc., decolorize function. Vitiligo have illness coming on to some extent increasing in recent years, may with development of industry, contact the chemical chance of material, increase and have something to do.
2.Oneself is immune the morbidity relation between immune theory of theory and vitiligo is paid attention to day by day. A lot of scholar notice patient and their family it amalgamates one's own immune diseases to be rate relatively high in the member, the common one has thyroiditis, hyperthyroidism or failing, diabetes, chronic renal gland function failing, pernicious anemia, rheumatic arthritis, malignant melanin tumour,etc.. And in the vitiligo patient's serum, the specific antibody of many kinds of organs of someone's detection, such as the gland antibody by resisting the thyroid gland antibody, resisting the cell antibody of coat of the stomach, resisting the renal gland antibody, resisting first form, resisting the smooth muscle antibody,etc., and detection rate is obviously high.
Persons who in addition suffer from one's own immune disease, the vitiligo morbidity is 10- 15 times higher than general crowd. Have found again recently the vitiligo patient has antibody of resisting surface antigen of black plain cell, called the vitiligo antibody, it relates to the fact that the patient skin pigment take off and lose the intensity that it drips degree, drip degree and decrease the area to expand and increase with the cover, find the animal which suffers from vitiligo has a similar phenomenon too, propose this disease is one's own immune disease of black plain cells. Behl(1977) Find, go on issues of the intersection of hickie and edge have monocytes assemble, invade the epidermis intersection of dermis, enter epidermis by basilar membrane that destroy, make dark plain cell and dark and plain and scarce of place this such as, think a disease may be one's own immune disease sending hypersensitivity late. In addition, take orally or for external use cortical hormone, until skin that leather festival is distribute decrease curative effect to be better, also prove the immune mechanism of a disease indirectly.

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